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產(chǎn)品名稱: N-Myc Antibody
產(chǎn)品型號(hào):
產(chǎn)品展商: immunoclone
產(chǎn)品文檔: 無(wú)相關(guān)文檔
簡(jiǎn)單介紹
N-Myc Antibody迅速增長(zhǎng)的產(chǎn)品線包括一抗、二抗、**測(cè)定及細(xì)胞檢測(cè)試劑盒、蛋白/多肽、激動(dòng)劑/拮抗劑/活化劑/抑制劑及裂解物等。N-Myc Antibody嚴(yán)格的質(zhì)量控制和驗(yàn)證實(shí)驗(yàn)包括各種不同的應(yīng)用：WB、細(xì)胞**熒光、**組化、流式細(xì)胞術(shù)、ELISA、CHIP、IP和peptide array。
N-Myc Antibody
的詳細(xì)介紹
N-Myc AntibodyProduct Profile
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Product Name
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N-Myc Antibody (C-19)
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Antibody Type
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Tags Antibodies
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Modification Notes
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The v-Myc oncogene, initially identified in the MC29 avian retrovirus, causes myelocytomas, carcinomas, sarcomas and lymphomas (1), and belongs to a family of oncogenes conserved throughout evolution. In humans, the family consists of five genes: c-Myc, N-Myc, R-Myc, L-Myc and B-Myc (2). Amplification of the N-Myc gene has been found in human neuroblastomas and cell lines (3,5). The extent of N-Myc amplification correlates well with the stage of neuroblastoma disease (4). Immunological studies have shown that the human N-Myc gene encodes a nuclear phosphoprotein (2) that exhibits relatively short (30 min) half life in vivo. The prototype member of the family, c-Myc p67, binds DNA in a sequence-specific manner subsequent to dimerization with a second basic region helix-loop-helix leucine zipper motif protein, designated Max (5-7).
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N-Myc AntibodyKey Feature
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Clonality
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Polyclonal
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Isotype
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IgG
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Host Species
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Rabbit
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Tested Applications
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WBIPIFELISA
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recommended for detection of N-Myc of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including equine, canine, bovine, porcine and avian:
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Species Reactivity
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HumanMouseRat
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Concentration
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200 μg/ml
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Purification
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Affinity purified
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N-Myc AntibodyTarget Information
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Alternative Names
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epitope mapping within the C-terminus of N-Myc of human origin
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Tissue Specificity
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epitope mapping within the C-terminus of N-Myc of human origin
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N-Myc AntibodyDatabase Links
N-Myc AntibodyApplication
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Application
Western blot analysis of N-Myc expression in non-transfected: (A) and mouse N-Myc transfected: (B) 293T whole cell lysates.
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Application Notes
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recommended for detection of N-Myc of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including equine, canine, bovine, porcine and avian:
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Additional Information
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Form
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Liquid
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Storage Instructions
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For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20oC or below. Avoid multiple freeze-thaw cycles.
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Storage Buffer
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phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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