p53 (phospho Thr387) Antibody
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產(chǎn)品名稱: p53 (phospho Thr387) Antibody
產(chǎn)品型號:
產(chǎn)品展商: immunoclone
產(chǎn)品文檔: 無相關(guān)文檔
簡單介紹
p53 (phospho Thr387) Antibody迅速增長的產(chǎn)品線包括一抗、二抗、**測定及細(xì)胞檢測試劑盒、蛋白/多肽、激動(dòng)劑/拮抗劑/活化劑/抑制劑及裂解物等。p53 (phospho Thr387) Antibody嚴(yán)格的質(zhì)量控制和驗(yàn)證實(shí)驗(yàn)包括各種不同的應(yīng)用：WB、細(xì)胞**熒光、**組化、流式細(xì)胞術(shù)、ELISA、CHIP、IP和peptide array。
p53 (phospho Thr387) Antibody
的詳細(xì)介紹
p53 (phospho Thr387) AntibodyProduct Profile
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Product Name
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p53 (phospho Thr387) Antibody
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Antibody Type
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Primary Antibodies
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Product description
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Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Implicated in Notch signaling cross-over.1) Zakut-Houri R., EMBO J. 4:1251-1255(1985).
More
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Immunogen
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p53 (phospho Thr387) antibody was raised against a peptide sequence around phosphorylation site of threonine 387 (F-K-T (p)-E-G) derived from Human p53.
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p53 (phospho Thr387) AntibodyKey Feature
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Clonality
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Polyclonal
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Isotype
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IgG
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Host Species
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Rabbit
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Tested Applications
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IHC
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Species Reactivity
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Human
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Concentration
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1mg/ml
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Purification
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Affinity purified
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p53 (phospho Thr387) AntibodyTarget Information
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Gene Symbol
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TP53
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Alternative Names
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TP53
tumor protein p53
Tumor suppressor p53
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Molecular Weight(MW)
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43 kDa
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Tissue Specificity
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The antibody detects endogenous levels of p53 only when phosphorylated at threonine 387.
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p53 (phospho Thr387) AntibodyDatabase Links
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Entrez Gene
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7157
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Protein Accession
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NP_000537.3
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p53 (phospho Thr387) AntibodyApplication
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Application
Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using p53 (Phospho-Thr387) antibody (left) or the same antibody preincubated with blocking peptide (right).
Additional Information
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Form
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Liquid
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Storage Instructions
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Store antibody at -20?C for up to one year.
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Storage Buffer
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Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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