p53 (phospho Ser6) Antibody
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產(chǎn)品名稱: p53 (phospho Ser6) Antibody
產(chǎn)品型號:
產(chǎn)品展商: immunoclone
產(chǎn)品文檔: 無相關(guān)文檔
簡單介紹
p53 (phospho Ser6) Antibody迅速增長的產(chǎn)品線包括一抗、二抗、**測定及細胞檢測試劑盒、蛋白/多肽、激動劑/拮抗劑/活化劑/抑制劑及裂解物等。p53 (phospho Ser6) Antibody嚴格的質(zhì)量控制和驗證實驗包括各種不同的應(yīng)用：WB、細胞**熒光、**組化、流式細胞術(shù)、ELISA、CHIP、IP和peptide array。
p53 (phospho Ser6) Antibody
的詳細介紹
p53 (phospho Ser6) AntibodyProduct Profile
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Product Name
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p53 (phospho Ser6) Antibody
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Antibody Type
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Primary Antibodies
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Product description
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Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Implicated in Notch signaling cross-over.1) Lin T, et al. (2005) Nat Cell Biol; 7 (2): 165-71. Vega FM, et al. (2004) Mol Cell Biol; 24 (23): 10366-80. Li J, et al. (2004) J Biol Chem; 279 (40): 41275-9. Wang J, et al. (2004) J Biol Chem; 279 (38): 39584-92.
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Immunogen
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p53 (Phospho-Ser6) antibody was raised against a peptide sequence around phosphorylation site of serine 6 (P-Q-S (p) -D-P) derived from Human p53.
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p53 (phospho Ser6) AntibodyKey Feature
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Clonality
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Polyclonal
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Host Species
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Rabbit
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Tested Applications
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IHCWB
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Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100:
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Species Reactivity
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HumanMouse
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Concentration
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1mg/ml
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Purification
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Affinity purified
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p53 (phospho Ser6) AntibodyTarget Information
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Gene Symbol
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TP53
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Alternative Names
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P53
BCC7
LFS1
TRP53
CHK1
Antigen NY-CO-13
Phosphoprotein p53
TP53
Tumor suppressor p53
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Molecular Weight(MW)
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53 kDa
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Tissue Specificity
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This antibody detects endogenous level of p53 only when phosphorylated at serine 6.
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p53 (phospho Ser6) AntibodyDatabase Links
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Entrez Gene
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7157
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Protein Accession
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NP_000537.3
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p53 (phospho Ser6) AntibodyApplication
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Application
Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using p53 (Phospho-Ser6).
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Application
Western blot analysis of lysed extracts from HT29 and HeLa cells untreated or treated with UV using p53 (Phospho-Ser6).
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Application Notes
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Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100:
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Additional Information
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Form
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Liquid
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Storage Instructions
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Store antibody at -20?C for up to one year.
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Storage Buffer
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Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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