Tau (phospho Ser416) Antibody
如果您對該產(chǎn)品感興趣的話,可以
產(chǎn)品名稱: Tau (phospho Ser416) Antibody
產(chǎn)品型號:
產(chǎn)品展商: immunoclone
產(chǎn)品文檔: 無相關文檔
簡單介紹
Tau (phospho Ser416) Antibody迅速增長的產(chǎn)品線包括一抗、二抗、**測定及細胞檢測試劑盒、蛋白/多肽、激動劑/拮抗劑/活化劑/抑制劑及裂解物等。Tau (phospho Ser416) Antibody嚴格的質量控制和驗證實驗包括各種不同的應用：WB、細胞**熒光、**組化、流式細胞術、ELISA、CHIP、IP和peptide array。
Tau (phospho Ser416) Antibody
的詳細介紹
Tau (phospho Ser416) AntibodyProduct Profile
|
Product Name
|
Tau (phospho Ser416) Antibody
|
|
Antibody Type
|
Primary Antibodies
|
|
Product description
|
Tau is a heterogeneous microtubule-associated protein that promotes and stabilizes microtubule assembly, especially in axons. Six isoforms with different amino-terminal inserts and different numbers of tandem repeats near the carboxy-terminus have been identified, and tau is hyperphosphorylated at approximately 25 sites by ERK, GSK-3 and CDK5 (1-2). Phosphorylation decreases the ability of tau to bind to microtubules. Neurofibrillary tangles are a major hallmark of Alzheimer's disease and these tangles are bundles of paired helical filaments composed of hyperphosphorylated tau. In particular, phosphorylation of Ser396 by GSK-3 or CDK5 destabilizes microtubules in Alzheimer's disease. Furthermore, inclusions of tau are found in a number of other neurodegenerative diseases, collectively known as tauopathies (1, 3).1) Johnson, G. V. and Stoothoff, W. H. (2004) J. Cell Sci. 117, 5721-5729. Hanger, D. P. et al. (1998) J. Neurochem. 71, 2465-2476. Bramblett, G. T. et al. (1993) Neuron 10, 1089-1099.
More
|
|
Immunogen
|
Tau (phospho-Ser416) antibody was raised against a peptide sequence around phosphorylation site of serine 416 (T-G-S (p) -I-D) derived from Rat Tau.
|
Tau (phospho Ser416) AntibodyKey Feature
|
Clonality
|
Polyclonal
|
|
Host Species
|
Rabbit
|
|
Tested Applications
|
WB
|
|
|
Western Blot: 1:500~1:1000:
|
|
Species Reactivity
|
Rat
|
|
Concentration
|
1mg/ml
|
|
Purification
|
Affinity purified
|
Tau (phospho Ser416) AntibodyTarget Information
|
Gene Symbol
|
Mapt
|
|
Alternative Names
|
pTau
Mtapt
RNPTAU
Mapt
More
|
|
Molecular Weight(MW)
|
48, 62, 78 kDa
|
|
Tissue Specificity
|
This antibody detects endogenous levels of Tau only when phosphorylated at serine 416.
|
Tau (phospho Ser416) AntibodyDatabase Links
|
Entrez Gene
|
29477
|
|
Protein Accession
|
NP_058908.2
|
Tau (phospho Ser416) AntibodyApplication
-
Application
Western blot analysis of extract from rat brain, rat hippocampus and mouse brain using Tau (phospho-Ser416).
|
Application Notes
|
Western Blot: 1:500~1:1000:
|
Additional Information
|
Form
|
Liquid
|
|
Storage Instructions
|
Store antibody at -20?C for up to one year.
|
|
Storage Buffer
|
Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
|
