Tau (phospho Ser404) Antibody
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產(chǎn)品名稱: Tau (phospho Ser404) Antibody
產(chǎn)品型號:
產(chǎn)品展商: immunoclone
產(chǎn)品文檔: 無相關(guān)文檔
簡單介紹
Tau (phospho Ser404) Antibody迅速增長的產(chǎn)品線包括一抗、二抗、**測定及細(xì)胞檢測試劑盒、蛋白/多肽、激動劑/拮抗劑/活化劑/抑制劑及裂解物等。Tau (phospho Ser404) Antibody嚴(yán)格的質(zhì)量控制和驗證實驗包括各種不同的應(yīng)用：WB、細(xì)胞**熒光、**組化、流式細(xì)胞術(shù)、ELISA、CHIP、IP和peptide array。
Tau (phospho Ser404) Antibody
的詳細(xì)介紹
Tau (phospho Ser404) AntibodyProduct Profile
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Product Name
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Tau (phospho Ser404) Antibody
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Antibody Type
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Primary Antibodies
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Product description
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Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by tau localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization.1) Li G, Yin H, et. al . (2004) J Biol Chem ; 279 (16): 15938-45. Noble W, et al. (2003) Neuron ; 38 (4): 555-65. Giasson BI, et al. (2002) . Biochemistry; 41 (51): 15376-87. Lee G., et. al. (1989) . Neuron 2:1615-1624. Andreadis A. et. al. (1992) Biochemistry 31:10626-10633.
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Immunogen
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Tau (Phospho-Ser404) antibody was raised against a peptide sequence around phosphorylation site of serine 404 (D-T-S (p) -P-R) derived from Human Tau.
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Tau (phospho Ser404) AntibodyKey Feature
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Clonality
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Polyclonal
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Host Species
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Rabbit
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Tested Applications
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IFIHCWB
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Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100, Immunofluorescence: 1:100~1:200:
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Species Reactivity
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HumanMouseRat
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Concentration
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1mg/ml
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Purification
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Affinity purified
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Tau (phospho Ser404) AntibodyTarget Information
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Gene Symbol
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MAPT
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Alternative Names
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TAU
MSTD
PPND
DDPAC
MAPTL
MTBT1
MTBT2
FTDP-17
JNKK1
MEK4
MKK4
PRKMK4
SEK1
SERK1
SKK1
MAPT
MTAPT
Neurofibrillary tangle protein
PHF-tau
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Molecular Weight(MW)
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48, 62, 78 kDa
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Tissue Specificity
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This antibody detects endogenous level of Tau only when phosphorylated at serine 404.
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Tau (phospho Ser404) AntibodyDatabase Links
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Entrez Gene
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4137
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Protein Accession
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NP_001116538.1
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Tau (phospho Ser404) AntibodyApplication
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Application
Western blot analysis of lysed extracts from mouse brain tissue using Tau (Phospho-Ser404).
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Application
Top Image: Immunohistochemical analysis of paraffin-embedded rat hippocampal region tissue from a model with Alzheimer’s Disease using Tau (Phospho-Ser404). Bottom Image: Immunofluorescence staining of methanol-fixed HeLa cells using Tau (Phospho-Ser404).
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Application Notes
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Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100, Immunofluorescence: 1:100~1:200:
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Additional Information
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Form
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Liquid
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Storage Instructions
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Store antibody at -20?C for up to one year.
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Storage Buffer
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Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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