EGFR (phospho Tyr1172) Antibody
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產(chǎn)品名稱: EGFR (phospho Tyr1172) Antibody
產(chǎn)品型號:
產(chǎn)品展商: immunoclone
產(chǎn)品文檔: 無相關(guān)文檔
簡單介紹
EGFR (phospho Tyr1172) Antibody迅速增長的產(chǎn)品線包括一抗、二抗、**測定及細胞檢測試劑盒、蛋白/多肽、激動劑/拮抗劑/活化劑/抑制劑及裂解物等。EGFR (phospho Tyr1172) Antibody嚴格的質(zhì)量控制和驗證實驗包括各種不同的應(yīng)用：WB、細胞**熒光、**組化、流式細胞術(shù)、ELISA、CHIP、IP和peptide array。
EGFR (phospho Tyr1172) Antibody
的詳細介紹
EGFR (phospho Tyr1172) AntibodyProduct Profile
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Product Name
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EGFR (phospho Tyr1172) Antibody
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Antibody Type
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Primary Antibodies
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Product description
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Receptor for EGF, but also for other members of the EGF family, as TGF-alpha, amphiregulin, betacellulin, heparin-binding EGF-like growth factor, GP30 and vaccinia virus growth factor. Is involved in the control of cell growth and differentiation. Phosphorylates MUC1 in breast cancer cells and increases the interaction of MUC1 with SRC and CTNNB1/beta-catenin.1) Noguchi T, et al. (1994) Mol Cell Biol 14 (10): 6674-6682Doherty JK, et al. (1999) Proc Natl Acad Sci U S A 96 (19): 10869-10874Kanner SB, et al. (1991) Mol Cell Biol 11 (2): 713-720Wu TT, et al. (1998) Mol Biol Cell 9 (7): 1661-1674O’Rourke DM, et al. (1997) Proc Natl Acad Sci U S A 94 (7): 3250-3255
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Immunogen
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EGFR (Phospho-Tyr1172) antibody was raised against a peptide sequence around phosphorylation site of tyrosine 1172 (P-D-Y (p) -Q-Q) derived from Human EGFR.
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EGFR (phospho Tyr1172) AntibodyKey Feature
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Clonality
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Polyclonal
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Host Species
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Rabbit
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Tested Applications
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IHCWB
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Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100:
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Species Reactivity
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HumanMouseRat
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Concentration
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1mg/ml
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Purification
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Affinity purified
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EGFR (phospho Tyr1172) AntibodyTarget Information
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Gene Symbol
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EGFR
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Alternative Names
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ERBB
HER1
mENA
ERBB1
PIG61
NBS
NBS1
P95
Receptor protein-tyrosine kinase ErbB-1
kinase EGFR
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Molecular Weight(MW)
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175 kDa
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Tissue Specificity
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This antibody detects endogenous level EGFR only when phosphorylated at tyrosine 1172.
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EGFR (phospho Tyr1172) AntibodyDatabase Links
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Entrez Gene
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1956
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Protein Accession
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NP_005219.2
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EGFR (phospho Tyr1172) AntibodyApplication
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Application
Western blot analysis of lysed extracts from A431 cells untreated or treated with EGF using EGFR (Phospho-Tyr1172).
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Application
Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using EGFR (Phospho-Tyr1172).
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Application Notes
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Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100:
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Additional Information
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Form
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Liquid
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Storage Instructions
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Store antibody at -20?C for up to one year.
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Storage Buffer
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Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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