AKT1 (phospho Ser473) Antibody
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產(chǎn)品名稱: AKT1 (phospho Ser473) Antibody
產(chǎn)品型號:
產(chǎn)品展商: immunoclone
產(chǎn)品文檔: 無相關(guān)文檔
簡單介紹
AKT1 (phospho Ser473) Antibody迅速增長的產(chǎn)品線包括一抗、二抗、**測定及細胞檢測試劑盒、蛋白/多肽、激動劑/拮抗劑/活化劑/抑制劑及裂解物等。AKT1 (phospho Ser473) Antibody嚴格的質(zhì)量控制和驗證實驗包括各種不同的應(yīng)用：WB、細胞**熒光、**組化、流式細胞術(shù)、ELISA、CHIP、IP和peptide array。
AKT1 (phospho Ser473) Antibody
的詳細介紹
AKT1 (phospho Ser473) AntibodyProduct Profile
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Product Name
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AKT1 (phospho Ser473) Antibody
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Antibody Type
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Primary Antibodies
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Product description
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AKT is a component of the PI-3 kinase pathway and is activated by phosphorylation at Ser 473 and Thr 308. AKT is a cytoplasmic protein also known as AKT1, Protein Kinase B (PKB) and rac (related to A and C kinases). AKT is a key regulator of many signal transduction pathways. AKT Exhibits tight control over cell proliferation and cell viability. Overexpression or inappropriate activation of AKT is noted in many types of cancer. AKT mediates many of the downstream events of PI 3-kinase (a lipid kinase activated by growth factors, cytokines and insulin). PI 3-kinase recruits AKT to the membrane, where it is activated by PDK1 phosphorylation. Once phos-phorylated, AKT dissociates from the membrane and phos-phorylates targets in the cytoplasm and the cell nucleus. AKT has two main roles: (i) inhibition of apoptosis; (ii) promotion of proliferation.
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Immunogen
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AKT1 antibody was raised against a peptide located in the phospho C-Terminus aa 460 - 480 of AKT1 (Human).
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AKT1 (phospho Ser473) AntibodyKey Feature
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Clonality
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Polyclonal
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Host Species
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Rabbit
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Tested Applications
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ELISAIHCWB
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AKT1 antibody can be used in ELISA starting at 1:000 - 1:1000, and immunohistochemistry starting at 5 μg/mL.:
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Species Reactivity
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HumanMouseRat
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Concentration
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1mg/ml
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Purification
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Affinity purified
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AKT1 (phospho Ser473) AntibodyTarget Information
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Gene Symbol
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AKT1
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Alternative Names
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AKT1
AKT
AKT-1
C-AKT
Pan-AKT
PKB alpha
PKBalpha
Proto-oncogene c-Akt
Protein kinase B
Rac protein kinase alpha
PRKBA
Protein kinase B alpha
RAC-PK-alpha
PKB
PKB-ALPHA
RAC
RAC-ALPHA
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Tissue Specificity
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pSer473
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AKT1 (phospho Ser473) AntibodyDatabase Links
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Entrez Gene
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207
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Protein Accession
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P31749
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AKT1 (phospho Ser473) AntibodyApplication
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Application
Immunohistochemistry staining of AKT1 in skeletal muscle tissue using AKT1 Antibody.
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Application
Immunohistochemistry staining of AKT1 in tonsil using AKT1 Antibody.
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Application Notes
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AKT1 antibody can be used in ELISA starting at 1:000 - 1:1000, and immunohistochemistry starting at 5 μg/mL.:
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Additional Information
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Form
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Liquid
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Storage Instructions
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Store AKT1 antibody at 4 ?C or -20 ?C. As with all antibodies avoid freeze/thaw cycles.
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Storage Buffer
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0.02 M potassium phosphate, 0.15 M sodium chloride, pH 7.2, 0.01% sodium azide.
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