Rb (phospho Ser807) Antibody
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產(chǎn)品名稱: Rb (phospho Ser807) Antibody
產(chǎn)品型號:
產(chǎn)品展商: immunoclone
產(chǎn)品文檔: 無相關(guān)文檔
簡單介紹
Rb (phospho Ser807) Antibody迅速增長的產(chǎn)品線包括一抗、二抗、**測定及細胞檢測試劑盒、蛋白/多肽、激動劑/拮抗劑/活化劑/抑制劑及裂解物等。Rb (phospho Ser807) Antibody嚴格的質(zhì)量控制和驗證實驗包括各種不同的應(yīng)用：WB、細胞**熒光、**組化、流式細胞術(shù)、ELISA、CHIP、IP和peptide array。
Rb (phospho Ser807) Antibody
的詳細介紹
Rb (phospho Ser807) AntibodyProduct Profile
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Product Name
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Rb (phospho Ser807) Antibody
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Antibody Type
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Primary Antibodies
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Product description
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Key regulator of entry into cell division that acts as a tumor suppressor. Acts as a transcription repressor of E2F1 target genes. The underphosphorylated, active form of RB1 interacts with E2F1 and represses its transcription activity, leading to cell cycle arrest. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases SUV39H1, SUV420H1 and SUV420H2, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Inhibits the intrinsic kinase activity of TAF1. In case of viral infections, interactions with SV40 large T antigen, HPV E7 protein or adenovirus E1A protein induce the disassembly of RB1-E2F1 complex thereby disrupting RB1's activity.1) Roesch A, et al. (2005) Mod Pathol. 18 (4): 565-572. Chadee DN, et al. (2004) Nat Cell Biol. 6 (8): 770-776. Knudsen ES, et al. (1997) Mol Cell Biol. 17 (10): 5771-5783. Knudsen ES, et al. (1996) J Biol Chem. 271 (14): 8313-8320.
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Immunogen
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Rb (Phospho-Ser807) antibody was raised against a peptide sequence around phosphorylation site of serine 807 (Y-I-S (p) -P-L) derived from Human Rb.
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Rb (phospho Ser807) AntibodyKey Feature
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Clonality
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Polyclonal
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Host Species
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Rabbit
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Tested Applications
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IHCWB
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Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100:
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Species Reactivity
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HumanMouseRat
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Concentration
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1mg/ml
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Purification
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Affinity purified
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Rb (phospho Ser807) AntibodyTarget Information
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Gene Symbol
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RB1
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Alternative Names
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RB
pRb
OSRC
pp110
p105-Rb
ERYF1
GF1
P105-RB
PP105
PP110
RB-1
RB1
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Molecular Weight(MW)
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110 kDa
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Tissue Specificity
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This antibody detects endogenous level of Rb only when phosphorylated at serine 807.
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Rb (phospho Ser807) AntibodyDatabase Links
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Entrez Gene
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5925
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Protein Accession
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NP_000312.2
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Rb (phospho Ser807) AntibodyApplication
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Application
Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using Rb (Phospho-Ser807).
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Application
Western blot analysis of lysed extracts from 3T3 cells untreated or treated with UV using Rb (Phospho-Ser807).
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Application Notes
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Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100:
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Additional Information
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Form
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Liquid
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Storage Instructions
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Store antibody at -20?C for up to one year.
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Storage Buffer
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Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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