FAK (phospho Tyr576 / Tyr577) Antibody
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產(chǎn)品名稱: FAK (phospho Tyr576 / Tyr577) Antibody
產(chǎn)品型號:
產(chǎn)品展商: immunoclone
產(chǎn)品文檔: 無相關文檔
簡單介紹
FAK (phospho Tyr576 / Tyr577) Antibody迅速增長的產(chǎn)品線包括一抗、二抗、**測定及細胞檢測試劑盒、蛋白/多肽、激動劑/拮抗劑/活化劑/抑制劑及裂解物等。FAK (phospho Tyr576 / Tyr577) Antibody嚴格的質(zhì)量控制和驗證實驗包括各種不同的應用：WB、細胞**熒光、**組化、流式細胞術、ELISA、CHIP、IP和peptide array。
FAK (phospho Tyr576 / Tyr577) Antibody
的詳細介紹
FAK (phospho Tyr576 / Tyr577) AntibodyProduct Profile
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Product Name
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FAK (phospho Tyr576 / Tyr577) Antibody
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Antibody Type
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Primary Antibodies
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Product description
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Non-receptor protein-tyrosine kinase implicated in signaling pathways involved in cell motility, proliferation and apoptosis. Activated by tyrosine-phosphorylation in response to either integrin clustering induced by cell adhesion or antibody cross-linking, or via G-protein coupled receptor (GPCR) occupancy by ligands such as bombesin or lysophosphatidic acid, or via LDL receptor occupancy. Plays a potential role in oncogenic transformations resulting in increased kinase activity.1) Parsons, J. T. et al. (2000) Oncogene 19, 5606-5613Schaller, M. D. et al. (1994) Mol. Cell. Biol. 14, 1680-1688. Cobb, B. S. et al. (1994) Mol. Cell. Biol. 14, 147-155. Chen, H. C. et al. (1996) J. Biol. Chem. 271, 26329-26334.
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Immunogen
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FAK (phospho-Tyr576/Tyr577) antibody was raised against a peptide sequence around phosphorylation site of tyrosine 576/tyrosine 577 (S-T-Y (p) -Y (p) -K-A) derived from Human FAK.
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FAK (phospho Tyr576 / Tyr577) AntibodyKey Feature
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Clonality
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Polyclonal
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Host Species
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Rabbit
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Tested Applications
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IFWB
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Western Blot: 1:500~1:1000, Immunofluorescence: 1:100~1:200:
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Species Reactivity
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Human
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Concentration
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1mg/ml
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Purification
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Affinity purified
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FAK (phospho Tyr576 / Tyr577) AntibodyTarget Information
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Gene Symbol
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PTK2
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Alternative Names
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FAK
FADK
FAK1
FRNK
PPP1R71
p125FAK
pp125FAK
EIF4F
EIF4G
EIF4GI
FADK 1
PTK2
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Molecular Weight(MW)
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125 kDa
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Tissue Specificity
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This antibody detects endogenous level of FAK only when phosphorylated at tyrosine 576/577.
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FAK (phospho Tyr576 / Tyr577) AntibodyDatabase Links
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Entrez Gene
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5747
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Protein Accession
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NP_005598.3
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FAK (phospho Tyr576 / Tyr577) AntibodyApplication
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Application
Immunofluorescence staining of methanol-fixed HeLa cells using FAK (phospho-Tyr576/Tyr577).
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Application
Western blot analysis of lysed extracts from HT29 cells untreated or treated with PMA using FAK (phospho-Tyr576/Tyr577).
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Application Notes
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Western Blot: 1:500~1:1000, Immunofluorescence: 1:100~1:200:
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Additional Information
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Form
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Liquid
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Storage Instructions
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Store antibody at -20?C for up to one year.
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Storage Buffer
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Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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