FAK (phospho Ser843) Antibody
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產(chǎn)品名稱: FAK (phospho Ser843) Antibody
產(chǎn)品型號:
產(chǎn)品展商: immunoclone
產(chǎn)品文檔: 無相關(guān)文檔
簡單介紹
FAK (phospho Ser843) Antibody迅速增長的產(chǎn)品線包括一抗、二抗、**測定及細(xì)胞檢測試劑盒、蛋白/多肽、激動(dòng)劑/拮抗劑/活化劑/抑制劑及裂解物等。FAK (phospho Ser843) Antibody嚴(yán)格的質(zhì)量控制和驗(yàn)證實(shí)驗(yàn)包括各種不同的應(yīng)用：WB、細(xì)胞**熒光、**組化、流式細(xì)胞術(shù)、ELISA、CHIP、IP和peptide array。
FAK (phospho Ser843) Antibody
的詳細(xì)介紹
FAK (phospho Ser843) AntibodyProduct Profile
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Product Name
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FAK (phospho Ser843) Antibody
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Antibody Type
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Primary Antibodies
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Product description
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Non-receptor protein-tyrosine kinase implicated in signaling pathways involved in cell motility, proliferation and apoptosis. Activated by tyrosine-phosphorylation in response to either integrin clustering induced by cell adhesion or antibody cross-linking, or via G-protein coupled receptor (GPCR) occupancy by ligands such as bombesin or lysophosphatidic acid, or via LDL receptor occupancy. Plays a potential role in oncogenic transformations resulting in increased kinase activity.1) Jiang X, Sinnett-Smith J, Rozengurt E (2007)Cell Signal 19, 1000-10 . Jacamo R, Jiang X, Lunn JA, Rozengurt E (2007)J Cell Physiol 210, 436-44. Le Boeuf F, Houle F, Sussman M, Huot J (2006)Mol Biol Cell 17, 3508-20 .
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Immunogen
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FAK (phospho Ser843) antibody was raised against a peptide sequence around phosphorylation site of serine843 (R-G-S (p)-I-D) derived from Human FAK .
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FAK (phospho Ser843) AntibodyKey Feature
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Clonality
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Polyclonal
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Isotype
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IgG
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Host Species
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Rabbit
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Tested Applications
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WB
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Western Blot: 1:500~1:1000:
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Species Reactivity
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HumanMouseRat
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Concentration
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1mg/ml
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Purification
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Affinity purified
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FAK (phospho Ser843) AntibodyTarget Information
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Gene Symbol
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PTK2
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Alternative Names
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FADK 1
FAK1
Focal adhesion kinase 1
PTK2
pp125FAK
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Molecular Weight(MW)
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120 kDa
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Tissue Specificity
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The antibody detects endogenous level of FAK only when phosphorylated at serine 843.
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FAK (phospho Ser843) AntibodyDatabase Links
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Entrez Gene
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5747
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Protein Accession
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NP_001186578.1
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FAK (phospho Ser843) AntibodyApplication
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Application
Western blot analysis of extracts from HepG2 cells treated with PMA using Phospho-FAK (Ser843) Antibody. The lane on the right is treated with the antigen-specific peptide.
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Application Notes
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Western Blot: 1:500~1:1000:
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Additional Information
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Form
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Liquid
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Storage Instructions
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Store antibody at -20?C for up to one year.
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Storage Buffer
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Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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