CREB (phospho Ser133) Antibody
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產(chǎn)品名稱: CREB (phospho Ser133) Antibody
產(chǎn)品型號(hào):
產(chǎn)品展商: immunoclone
產(chǎn)品文檔: 無相關(guān)文檔
簡單介紹
CREB (phospho Ser133) Antibody迅速增長的產(chǎn)品線包括一抗、二抗、**測(cè)定及細(xì)胞檢測(cè)試劑盒、蛋白/多肽、激動(dòng)劑/拮抗劑/活化劑/抑制劑及裂解物等。CREB (phospho Ser133) Antibody嚴(yán)格的質(zhì)量控制和驗(yàn)證實(shí)驗(yàn)包括各種不同的應(yīng)用：WB、細(xì)胞**熒光、**組化、流式細(xì)胞術(shù)、ELISA、CHIP、IP和peptide array。
CREB (phospho Ser133) Antibody
的詳細(xì)介紹
CREB (phospho Ser133) AntibodyProduct Profile
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Product Name
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CREB (phospho Ser133) Antibody
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Antibody Type
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Primary Antibodies
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Product description
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CREB1 is a transcription factor that is a member of the bZIP family of DNA binding proteins. It binds as a homodimer to the CRE (cAMP-Responsive Element), an octameric palindrome containing a conserved core sequence, 5-prime-TGACG-3-prime. It consists of two transcript variants encoding respective isoforms produced by alternate splicing. It is mapped to 2q32.3-q34 . It is phosphorylated by several protein kinases and induces transcription of genes in response to hormonal stimulation of the cAMP pathway. CREB1 is crucial for the consolidation of long-term conditioned fear memories, but not for encoding, storage, or retrieval of these memories. It is required for the stability of reactivated or retrieved conditioned fear memories .1) Xing J, et al. (1998) Mol Cell Biol 18 (4): 1946-55. Tan Y, et al. (1996) EMBO J; 15 (17): 4629-42. Hao, M. et al. (1996) J. Biol. Chem. 271, 29380-29385. Mayo LD, et al. (2001) Biol Chem; 276 (27): 25184-9.
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Immunogen
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CREB (Phospho-Ser133) antibody was raised against a peptide sequence around phosphorylation site of serine 133 (R-P-S (p) -Y-R) derived from Human CREB.
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CREB (phospho Ser133) AntibodyKey Feature
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Clonality
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Polyclonal
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Host Species
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Rabbit
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Tested Applications
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IHCWB
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Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100:
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Species Reactivity
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Human
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Concentration
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1mg/ml
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Purification
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Affinity purified
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CREB (phospho Ser133) AntibodyTarget Information
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Gene Symbol
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CREB1
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Alternative Names
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CREB
CCNB
CREB-1
CREB1
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Molecular Weight(MW)
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43 kDa
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Tissue Specificity
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This antibody detects endogenous level of CREB only when phosphorylated at serine 133.
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CREB (phospho Ser133) AntibodyDatabase Links
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Entrez Gene
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1385
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Protein Accession
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NP_004370.1
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CREB (phospho Ser133) AntibodyApplication
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Application
Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using CREB (Phospho-Ser133).
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Application
Western blot analysis of lysed extracts from HeLa cells untreated or treated with UV using CREB (Phospho-Ser133).
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Application Notes
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Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100:
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Additional Information
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Form
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Liquid
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Storage Instructions
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Store antibody at -20?C for up to one year.
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Storage Buffer
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Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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