4E-BP1 (phospho Thr70) Antibody
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產(chǎn)品名稱: 4E-BP1 (phospho Thr70) Antibody
產(chǎn)品型號:
產(chǎn)品展商: immunoclone
產(chǎn)品文檔: 無相關(guān)文檔
簡單介紹
4E-BP1 (phospho Thr70) Antibody迅速增長的產(chǎn)品線包括一抗、二抗、**測定及細(xì)胞檢測試劑盒、蛋白/多肽、激動劑/拮抗劑/活化劑/抑制劑及裂解物等。4E-BP1 (phospho Thr70) Antibody嚴(yán)格的質(zhì)量控制和驗證實驗包括各種不同的應(yīng)用：WB、細(xì)胞**熒光、**組化、流式細(xì)胞術(shù)、ELISA、CHIP、IP和peptide array。
4E-BP1 (phospho Thr70) Antibody
的詳細(xì)介紹
4E-BP1 (phospho Thr70) AntibodyProduct Profile
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Product Name
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4E-BP1 (phospho Thr70) Antibody
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Antibody Type
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Primary Antibodies
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Product description
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4E-BP1 encodes one member of a family of translation repressor proteins. The protein directly interacts with eukaryotic translation initiation factor 4E (eIF4E), which is a limiting component of the multisubunit complex that recruits 40S ribosomal subunits to the 5' end of mRNAs. Interaction of this protein with eIF4E inhibits complex assembly and represses translation. This protein is phosphorylated in response to various signals including UV irradiation and insulin signaling, resulting in its dissociation from eIF4E and activation of mRNA translation.1) Pause A., Nature 371:762-767(1994).
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Immunogen
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4E-BP1 (phospho Thr70) antibody was raised against a peptide sequence around phosphorylation site of threonine70 (T-K-T (p)-P-P) derived from Human 4E-BP1.
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4E-BP1 (phospho Thr70) AntibodyKey Feature
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Clonality
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Polyclonal
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Isotype
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IgG
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Host Species
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Rabbit
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Tested Applications
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IHC
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Species Reactivity
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Human
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Concentration
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1mg/ml
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Purification
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Affinity purified
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4E-BP1 (phospho Thr70) AntibodyTarget Information
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Gene Symbol
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EIF4EBP1
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Alternative Names
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4EBP1
P/OKCL.6
P/OKCL.6
PHAS-I
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Molecular Weight(MW)
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12 kDa
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Tissue Specificity
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The antibody detects endogenous levels of 4E-BP1 only when phosphorylated at threonine 70.
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4E-BP1 (phospho Thr70) AntibodyDatabase Links
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Entrez Gene
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1978
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Protein Accession
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NP_004086.1
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4E-BP1 (phospho Thr70) AntibodyApplication
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Application
Immunohistochemical analysis of paraffin-embedded human colon carcinoma tissue using 4E-BP1 (Phospho-Thr70) antibody (left) or the same antibody preincubated with blocking peptide (right).
Additional Information
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Form
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Liquid
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Storage Instructions
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Store antibody at -20?C for up to one year.
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Storage Buffer
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Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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