BAD (phospho Ser112) Antibody
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產(chǎn)品名稱: BAD (phospho Ser112) Antibody
產(chǎn)品型號:
產(chǎn)品展商: immunoclone
產(chǎn)品文檔: 無相關(guān)文檔
簡單介紹
BAD (phospho Ser112) Antibody迅速增長的產(chǎn)品線包括一抗、二抗、**測定及細(xì)胞檢測試劑盒、蛋白/多肽、激動劑/拮抗劑/活化劑/抑制劑及裂解物等。BAD (phospho Ser112) Antibody嚴(yán)格的質(zhì)量控制和驗(yàn)證實(shí)驗(yàn)包括各種不同的應(yīng)用：WB、細(xì)胞**熒光、**組化、流式細(xì)胞術(shù)、ELISA、CHIP、IP和peptide array。
BAD (phospho Ser112) Antibody
的詳細(xì)介紹
BAD (phospho Ser112) AntibodyProduct Profile
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Product Name
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BAD (phospho Ser112) Antibody
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Antibody Type
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Primary Antibodies
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Product description
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The protein encoded by BAD gene is a member of the BCL-2 family. BCL-2 family members are known to be regulators of programmed cell death. This protein positively regulates cell apoptosis by forming heterodimers with BCL-xL and BCL-2, and reversing their death repressor activity. Proapoptotic activity of this protein is regulated through its phosphorylation. Protein kinases AKT and MAP kinase, as well as protein phosphatase calcineurin were found to be involved in the regulation of this protein. Alternative splicing of this gene results in two transcript variants which encode the same isoform.1) Zhang B, et al. (2004) . Mol Cell Biol. 24 (14): 6205-6214. Rice PL, et al. (2003) . Cancer Res. 63 (3): 616-620. Wang XQ, et al. (2001) . J Biol Chem. 276 (48): 44504-44511.
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Immunogen
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BAD (Phospho-Ser112) antibody was raised against a peptide sequence around phosphorylation site of serine 112 (H-S-S (p) -Y-P) derived from Human BAD.
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BAD (phospho Ser112) AntibodyKey Feature
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Clonality
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Polyclonal
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Host Species
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Rabbit
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Tested Applications
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IHCWB
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Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100:
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Species Reactivity
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HumanMouseRat
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Concentration
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1mg/ml
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Purification
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Affinity purified
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BAD (phospho Ser112) AntibodyTarget Information
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Gene Symbol
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BAD
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Alternative Names
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BBC2
BCL2L8
ERBB
ERBB1
HER1
BBC6
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Molecular Weight(MW)
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23 kDa
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Tissue Specificity
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This antibody detects endogenous level of BAD only when phosphorylated at serine 112.
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BAD (phospho Ser112) AntibodyDatabase Links
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Entrez Gene
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572
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Protein Accession
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NP_004313.1
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BAD (phospho Ser112) AntibodyApplication
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Application
Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using BAD (Phospho-Ser112).
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Application
Western blot analysis of lysed extracts from cos7 cells untreated or treated with EGF using BAD (Phospho-Ser112).
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Application Notes
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Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100:
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Additional Information
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Form
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Liquid
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Storage Instructions
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Store antibody at -20?C for up to one year.
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Storage Buffer
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Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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