FKHR (phospho Ser319) Antibody
如果您對該產(chǎn)品感興趣的話,可以
產(chǎn)品名稱: FKHR (phospho Ser319) Antibody
產(chǎn)品型號:
產(chǎn)品展商: immunoclone
產(chǎn)品文檔: 無相關(guān)文檔
簡單介紹
FKHR (phospho Ser319) Antibody迅速增長的產(chǎn)品線包括一抗、二抗、**測定及細(xì)胞檢測試劑盒、蛋白/多肽、激動劑/拮抗劑/活化劑/抑制劑及裂解物等。FKHR (phospho Ser319) Antibody嚴(yán)格的質(zhì)量控制和驗(yàn)證實(shí)驗(yàn)包括各種不同的應(yīng)用：WB、細(xì)胞**熒光、**組化、流式細(xì)胞術(shù)、ELISA、CHIP、IP和peptide array。
FKHR (phospho Ser319) Antibody
的詳細(xì)介紹
FKHR (phospho Ser319) AntibodyProduct Profile
|
Product Name
|
FKHR (phospho Ser319) Antibody
|
|
Antibody Type
|
Primary Antibodies
|
|
Product description
|
FKHR belongs to the forkhead family of transcription factors, which are characterized by a distinct forkhead domain. It may play a role in myogenic growth and differentiation. The mammalian DAF-16-like transcription factors, FKHR, FKHRL1, and AFX, function as key regulators of insulin signaling, cell cycle progression, and apoptosis downstream of phosphoinositide 3-kinase. Gene activation through binding to insulin response sequences has been essential for mediating these functions. D-type Cyclins (in Class III) is required for FKHR mediated inhibition of cell cycle progression and transformation. FKHR gene is mapped to chromosome 13q141) Rena G, et al. (2002) EMBO J 21 (9): 2263-2271. Woods YL, et al. (2001) Biochem J355 (Pt 3): 597-607. Rena G, et al. (2001) Biochem J 354 (Pt 3): 605-612.
More
|
|
Immunogen
|
FKHR (Phospho-Ser319) antibody was raised against a peptide sequence around phosphorylation site of serine 319 (T-S-S (p) -N-A) derived from Human FKHR/FOXO1A.
|
FKHR (phospho Ser319) AntibodyKey Feature
|
Clonality
|
Polyclonal
|
|
Host Species
|
Rabbit
|
|
Tested Applications
|
IFIHCWB
|
|
|
Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100, Immunofluorescence: 1:100~1:200:
|
|
Species Reactivity
|
HumanMouse
|
|
Concentration
|
1mg/ml
|
|
Purification
|
Affinity purified
|
FKHR (phospho Ser319) AntibodyTarget Information
|
Gene Symbol
|
FOXO1
|
|
Alternative Names
|
FKH1
FKHR
FOXO1A
MEK2
MKK2
PRKMK2
FOXO1
More
|
|
Molecular Weight(MW)
|
78 - 82 kDa
|
|
Tissue Specificity
|
This antibody detects endogenous level of FKHR only when phosphorylated at serine 319.
|
FKHR (phospho Ser319) AntibodyDatabase Links
|
Entrez Gene
|
2308
|
|
Protein Accession
|
NP_002006.2
|
FKHR (phospho Ser319) AntibodyApplication
-
Application
Top Image: Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using FKHR (Phospho-Ser319). Bottom Image: Immunofluorescence staining of methanol-fixed HeLa cells using FKHR (Phospho-Ser319).
-
Application
Western blot analysis of lysed extracts from 3T3 cells untreated or treated with serum starvation using FKHR (Phospho-Ser319).
|
Application Notes
|
Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100, Immunofluorescence: 1:100~1:200:
|
Additional Information
|
Form
|
Liquid
|
|
Storage Instructions
|
Store antibody at -20?C for up to one year.
|
|
Storage Buffer
|
Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
|
