This receptor binds insulin-like growth factor 1 (IGF1) with a high affinity and IGF2 with a lower affinity. It has a tyrosine-protein kinase activity, which is necessary for the activation of the IGF1-stimulated downstream signaling cascade. When present in a hybrid receptor with INSR, binds IGF1.1) Adams, T. E. et al. (2000) Cell. Mol. Life Sci. 57, 1050-1093Baserga, R. et al. (2000) Oncogene 19, 5574-5581Scheidegger, K. J. et al. (2000) J. Biol. Chem. 275, 38921-38928. O'Connor R, et al. Mol Cell Biol 1997 Jan; 17 (1): 427-35
IGF-1R (Ab-1346) antibody was raised against a peptide sequence around aa.1344~1348 (Q-P-Y-A-H) derived from Human IGF-1R .
IHCWB
HumanMouseRat
Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using IGF-1R (Ab-1346).
Western blot analysis of lysed extracts from 293 cells using IGF-1R (Ab-1346).
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