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產(chǎn)品名稱(chēng): op18 Antibody
產(chǎn)品型號(hào):
產(chǎn)品展商: immunoclone
產(chǎn)品文檔: 無(wú)相關(guān)文檔
簡(jiǎn)單介紹
op18 Antibody迅速增長(zhǎng)的產(chǎn)品線包括一抗、二抗、**測(cè)定及細(xì)胞檢測(cè)試劑盒、蛋白/多肽、激動(dòng)劑/拮抗劑/活化劑/抑制劑及裂解物等。op18 Antibody嚴(yán)格的質(zhì)量控制和驗(yàn)證實(shí)驗(yàn)包括各種不同的應(yīng)用：WB、細(xì)胞**熒光、**組化、流式細(xì)胞術(shù)、ELISA、CHIP、IP和peptide array。
op18 Antibody
的詳細(xì)介紹
op18 AntibodyProduct Profile
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Product Name
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op18 Antibody
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Antibody Type
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Primary Antibodies
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Product description
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op18 Antibody: Op18 belongs to the stathmin family of genes and encodes a ubiquitous cytosolic phosphoprotein that may function as an intracellular relay integrating several signaling pathways such as those involved in cell proliferation and differentiation. Op18 has also been shown to be involved in the regulation of the microtubule filament system by destabilizing microtubules, thereby preventing assembly and promoting the disassembly of microtubules. More recently, op18 has been implicated as a potential target of the ASK1-p38 MAP kinase cascade, suggesting that the ASK1-p38 cascade may regulate microtubule dynamics through op18. Op18 is highly expressed in a wide variety of human malignancies, including leukemia, prostate cancer, ovarian carcinoma, and breast carcinoma, suggesting that op18 may be an ideal target for anti-cancer therapeutics.1) Curmi PA, Gavet O, Charbaut E, et al. Stathmin and its phosphoprotein family: general properties, biochemical and functional interaction with tubulin. Cell Structure and Function1999; 24:345-57.
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Immunogen
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Op18 antibody was raised against a 17 amino acid synthetic peptide from near the amino terminus of human op18. The immunogen is located within the first 50 amino acids of op18.
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op18 AntibodyKey Feature
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Clonality
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Polyclonal
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Isotype
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IgG
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Host Species
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Rabbit
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Tested Applications
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ELISAIFIHC-PWB
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Op18 antibody can be used for detection of op18 by Western blot at 0.5 - 1 μg/mL. Antibody can also be used for immunohistochemistry starting at 2.5 μg/mL. For immunofluorescence start at 20 μg/mL.:
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Species Reactivity
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HumanMouseRat
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Concentration
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1mg/ml
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Purification
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Affinity purified
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op18 AntibodyTarget Information
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Gene Symbol
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STMN1
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Alternative Names
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op18 Antibody: Lag
SMN
OP18
PP17
PP19
PR22
LAP18
C1orf215
Stathmin
Leukemia-associated phosphoprotein p18
Op18
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Sequence Similarities
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2) Cat. No. 10-301 - Human Brain Tissue Slide
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op18 AntibodyDatabase Links
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Entrez Gene
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3925
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Protein Accession
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AAH82228
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op18 AntibodyApplication
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Application
Immunohistochemistry of op18 in human brain tissue with op18 antibody at 2.5 μg/mL.
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Application
Western blot analysis of op18 in human brain tissue lysate with op18 antibody at (A) 0.5 and (B) 1 μg/mL.
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Application
Immunofluorescence of op18 in human brain tissue with op18 antibody at 20 μg/mL.
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Positive Control
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1) Cat. No. 1303 - Human Brain Tissue Lysate
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Application Notes
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Op18 antibody can be used for detection of op18 by Western blot at 0.5 - 1 μg/mL. Antibody can also be used for immunohistochemistry starting at 2.5 μg/mL. For immunofluorescence start at 20 μg/mL.:
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Additional Information
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Form
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Liquid
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Storage Instructions
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op18 antibody can be stored at 4?C for three months and -20?C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
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Storage Buffer
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op18 Antibody is supplied in PBS containing 0.02% sodium azide.
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