APP (phospho 668) Antibody
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產(chǎn)品名稱: APP (phospho 668) Antibody
產(chǎn)品型號:
產(chǎn)品展商: immunoclone
產(chǎn)品文檔: 無相關(guān)文檔
簡單介紹
APP (phospho 668) Antibody迅速增長的產(chǎn)品線包括一抗、二抗、**測定及細(xì)胞檢測試劑盒、蛋白/多肽、激動劑/拮抗劑/活化劑/抑制劑及裂解物等。APP (phospho 668) Antibody嚴(yán)格的質(zhì)量控制和驗(yàn)證實(shí)驗(yàn)包括各種不同的應(yīng)用：WB、細(xì)胞**熒光、**組化、流式細(xì)胞術(shù)、ELISA、CHIP、IP和peptide array。
APP (phospho 668) Antibody
的詳細(xì)介紹
APP (phospho 668) AntibodyProduct Profile
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Product Name
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APP (phospho 668) Antibody
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Antibody Type
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Primary Antibodies
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Product description
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APP encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy). Multiple transcript variants encoding several different isoforms have been found for this gene.1) Hung, A. Y. and Selkoe, D. J. (1994) EMBO J. 13, 534-542. Suzuki, T. et al. (1994) EMBO J. 13, 1114-1122Ando, K. et al. (1999) J. Neurosci. 19, 4421-4427. Iijima, K. I. et al. (2000) J. Neurochem. 75, 1085-1091
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Immunogen
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APP (Phospho-668) antibody was raised against a peptide sequence around phosphorylation site of threonine 668 (A-V-T (p) -P-E) derived from Human APP.
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APP (phospho 668) AntibodyKey Feature
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Clonality
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Polyclonal
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Host Species
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Rabbit
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Tested Applications
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WB
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Western Blot: 1:500~1:1000:
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Species Reactivity
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HumanMouseRat
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Concentration
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1mg/ml
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Purification
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Affinity purified
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APP (phospho 668) AntibodyTarget Information
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Gene Symbol
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APP
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Alternative Names
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AAA
AD1
PN2
ABPP
APPI
CVAP
ABETA
PN-II
CTFgamma
Nrage
AAA
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Molecular Weight(MW)
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100 - 140 kDa
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Tissue Specificity
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This antibody detects endogenous level of APP only when phosphorylated at threonine 668.
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APP (phospho 668) AntibodyDatabase Links
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Entrez Gene
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351
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Protein Accession
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NP_000475.1
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APP (phospho 668) AntibodyApplication
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Application
Western blot analysis of lysed extracts from mouse brain tissue using APP (Phospho-668).
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Application Notes
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Western Blot: 1:500~1:1000:
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Additional Information
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Form
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Liquid
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Storage Instructions
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Store antibody at -20?C for up to one year.
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Storage Buffer
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Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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