Amyloid beta A4 (phospho Thr743/668) Antibody
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產(chǎn)品名稱: Amyloid beta A4 (phospho Thr743/668) Antibody
產(chǎn)品型號:
產(chǎn)品展商: immunoclone
產(chǎn)品文檔: 無相關文檔
簡單介紹
Amyloid beta A4 (phospho Thr743/668) Antibody迅速增長的產(chǎn)品線包括一抗、二抗、**測定及細胞檢測試劑盒、蛋白/多肽、激動劑/拮抗劑/活化劑/抑制劑及裂解物等。Amyloid beta A4 (phospho Thr743/668) Antibody嚴格的質(zhì)量控制和驗證實驗包括各種不同的應用：WB、細胞**熒光、**組化、流式細胞術、ELISA、CHIP、IP和peptide array。
Amyloid beta A4 (phospho Thr743/668) Antibody
的詳細介紹
Amyloid beta A4 (phospho Thr743/668) AntibodyProduct Profile
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Product Name
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Amyloid beta A4 (phospho Thr743/668) Antibody
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Antibody Type
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Primary Antibodies
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Product description
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Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions. Can promote transcription activation through binding to APBB1-KAT5 and inhibits Notch signaling through interaction with Numb. Couples to apoptosis-inducing pathways such as those mediated by G(O) and JIP. Inhibits G(o) alpha ATPase activity By similarity. Acts as a kinesin I membrane receptor, mediating the axonal transport of beta-secretase and presenilin 1.1) Ming-Sum Lee J. Cell Biol., Oct 2003; 163: 83.
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Immunogen
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Amyloid beta A4 (phospho Thr743/668) antibody was raised against a peptide sequence around phosphorylation site of threonine 743 /668 (A-V-T (p)-P-E) derived from Human Amyloid beta A4.
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Amyloid beta A4 (phospho Thr743/668) AntibodyKey Feature
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Clonality
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Polyclonal
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Isotype
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IgG
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Host Species
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Rabbit
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Tested Applications
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IFIHCWB
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Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100, Immunofluorescence: 1:100~1:200:
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Species Reactivity
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HumanMouseRat
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Concentration
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1mg/ml
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Purification
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Affinity purified
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Amyloid beta A4 (phospho Thr743/668) AntibodyTarget Information
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Gene Symbol
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APP
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Alternative Names
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A4
AD1
APP
APPI
Beta-amyloid protein 42
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Molecular Weight(MW)
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140 kDa
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Tissue Specificity
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The antibody detects endogenous levels of Amyloid beta A4 only when phosphorylated at threonine 743/668.
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Amyloid beta A4 (phospho Thr743/668) AntibodyDatabase Links
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Entrez Gene
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351
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Protein Accession
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NP_000475.1
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Amyloid beta A4 (phospho Thr743/668) AntibodyApplication
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Application
Immunofluorescence staining of methanol-fixed HeLa cells using Amyloid beta A4 (phospho-Thr743/668) Antibody.
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Application
Western blot analysis of extracts from cos-7 cells (Lane 2), using Amyloid beta A4 (Phospho-Thr743/668) Antibody. The lane on the left is treated with antigen-specific peptide.
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Application
Immunohistochemical analysis of paraffin-embedded human brain tissue using Amyloid beta A4 (phospho-Thr743/668) antibody (left) or the same antibody preincubated with blocking peptide (right).
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Application Notes
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Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100, Immunofluorescence: 1:100~1:200:
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Additional Information
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Form
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Liquid
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Storage Instructions
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Store antibody at -20?C for up to one year.
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Storage Buffer
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Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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