p27Kip1 (phospho Thr187) Antibody
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產(chǎn)品名稱: p27Kip1 (phospho Thr187) Antibody
產(chǎn)品型號:
產(chǎn)品展商: immunoclone
產(chǎn)品文檔: 無相關(guān)文檔
簡單介紹
p27Kip1 (phospho Thr187) Antibody迅速增長的產(chǎn)品線包括一抗、二抗、**測定及細(xì)胞檢測試劑盒、蛋白/多肽、激動劑/拮抗劑/活化劑/抑制劑及裂解物等。p27Kip1 (phospho Thr187) Antibody嚴(yán)格的質(zhì)量控制和驗(yàn)證實(shí)驗(yàn)包括各種不同的應(yīng)用：WB、細(xì)胞**熒光、**組化、流式細(xì)胞術(shù)、ELISA、CHIP、IP和peptide array。
p27Kip1 (phospho Thr187) Antibody
的詳細(xì)介紹
p27Kip1 (phospho Thr187) AntibodyProduct Profile
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Product Name
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p27Kip1 (phospho Thr187) Antibody
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Antibody Type
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Primary Antibodies
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Product description
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Important regulator of cell cycle progression. Involved in G1 arrest. Potent inhibitor of cyclin E- and cyclin A-CDK2 complexes. Positive regulator of cyclin D-dependent kinases such as CDK4. Regulated by phosphorylation and degradation events.1) Eguchi H, et al. (2003) Cancer Res; 63 (15): 4739-46Le XF, et al. (2003) J Biol Chem;Connor MK, et al. (2003) ) Mol Biol Cell; 14 (1): 201-13Fujita N, et al. (2002) J Biol Chem; 277 (32): 28706-13Ishida N, et al. (2000) J Biol Chem; 275 (33): 25146-54
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Immunogen
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p27Kip1 (Phospho-Thr187) antibody was raised against a peptide sequence around phosphorylation site of threonine 187 (E-Q-T (p) -P-K) derived from Human p27Kip1.
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p27Kip1 (phospho Thr187) AntibodyKey Feature
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Clonality
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Polyclonal
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Host Species
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Rabbit
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Tested Applications
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IHCWB
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Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100:
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Species Reactivity
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HumanMouseRat
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Concentration
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1mg/ml
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Purification
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Affinity purified
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p27Kip1 (phospho Thr187) AntibodyTarget Information
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Gene Symbol
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CDKN1B
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Alternative Names
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KIP1
MEN4
CDKN4
MEN1B
P27KIP1
MAPTL
MTBT1
TAU
CDKN1B
CDN1B
Cyclin-dependent kinase inhibitor 1B
Cyclin-dependent kinase inhibitor p27
KIP1
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Molecular Weight(MW)
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27 kDa
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Tissue Specificity
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This antibody detects endogenous level of p27Kip1 only when phosphorylated at threonine 187.
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p27Kip1 (phospho Thr187) AntibodyDatabase Links
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Entrez Gene
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1027
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Protein Accession
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NP_004055.1
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p27Kip1 (phospho Thr187) AntibodyApplication
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Application
Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using p27Kip1 (Phospho-Thr187).
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Application
Western blot analysis of lysed extracts from HeLa cells untreated or treated with EGF, IFN-α using p27Kip1 (Phospho-Thr187).
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Application Notes
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Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100:
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Additional Information
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Form
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Liquid
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Storage Instructions
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Store antibody at -20?C for up to one year.
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Storage Buffer
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Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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