Caspase 9 (phospho Thr125) Antibody
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產(chǎn)品名稱: Caspase 9 (phospho Thr125) Antibody
產(chǎn)品型號:
產(chǎn)品展商: immunoclone
產(chǎn)品文檔: 無相關(guān)文檔
簡單介紹
Caspase 9 (phospho Thr125) Antibody迅速增長的產(chǎn)品線包括一抗、二抗、**測定及細(xì)胞檢測試劑盒、蛋白/多肽、激動劑/拮抗劑/活化劑/抑制劑及裂解物等。Caspase 9 (phospho Thr125) Antibody嚴(yán)格的質(zhì)量控制和驗證實驗包括各種不同的應(yīng)用：WB、細(xì)胞**熒光、**組化、流式細(xì)胞術(shù)、ELISA、CHIP、IP和peptide array。
Caspase 9 (phospho Thr125) Antibody
的詳細(xì)介紹
Caspase 9 (phospho Thr125) AntibodyProduct Profile
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Product Name
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Caspase 9 (phospho Thr125) Antibody
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Antibody Type
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Primary Antibodies
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Product description
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Involved in the activation cascade of caspases responsible for apoptosis execution. Binding of caspase-9 to Apaf-1 leads to activation of the protease which then cleaves and activates caspase-3. Proteolytically cleaves poly(ADP-ribose) polymerase (PARP). Isoform 2 lacks activity is an dominant-negative inhibitor of caspase-9.1) Duan H., J. Biol. Chem. 271:16720-16724(1996).
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Immunogen
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Caspase 9 (phospho Thr125) antibody was raised against a peptide sequence around phosphorylation site of threonine 125 (P-E-T (p)-P-R) derived from Human Caspase 9.
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Caspase 9 (phospho Thr125) AntibodyKey Feature
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Clonality
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Polyclonal
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Isotype
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IgG
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Host Species
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Rabbit
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Tested Applications
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IHCWB
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Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100:
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Species Reactivity
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HumanMouseRat
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Concentration
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1mg/ml
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Purification
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Affinity purified
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Caspase 9 (phospho Thr125) AntibodyTarget Information
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Gene Symbol
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CASP9
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Alternative Names
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APAF-3
MCH6
RNCASP9
CASP-9
ICE-LAP6
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Molecular Weight(MW)
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47 kDa
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Tissue Specificity
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The antiserum was produced against synthesized phosphopeptide derived from human Caspase 9 around the phosphorylation site of threonine 125 (P-E-TP-P-R).
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Caspase 9 (phospho Thr125) AntibodyDatabase Links
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Entrez Gene
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842
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Protein Accession
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NP_001220.2
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Caspase 9 (phospho Thr125) AntibodyApplication
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Application
Immunohistochemical analysis of paraffin-embedded human lung carcinoma tissue using Caspase 9 (Phospho-Thr125) antibody (left) or the same antibody preincubated with blocking peptide (right).
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Application
Western blot analysis of extracts from HeLa cells treated with TNF using Caspase 9 (Phospho-Thr125) Antibody. The lane on the right is treated with the antigen-specific peptide.
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Application Notes
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Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100:
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Additional Information
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Form
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Liquid
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Storage Instructions
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Store antibody at -20?C for up to one year.
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Storage Buffer
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Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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