p90 RSK (phospho Thr573) Antibody
如果您對該產(chǎn)品感興趣的話,可以
產(chǎn)品名稱: p90 RSK (phospho Thr573) Antibody
產(chǎn)品型號:
產(chǎn)品展商: immunoclone
產(chǎn)品文檔: 無相關(guān)文檔
簡單介紹
p90 RSK (phospho Thr573) Antibody迅速增長的產(chǎn)品線包括一抗、二抗、**測定及細胞檢測試劑盒、蛋白/多肽、激動劑/拮抗劑/活化劑/抑制劑及裂解物等。p90 RSK (phospho Thr573) Antibody嚴格的質(zhì)量控制和驗證實驗包括各種不同的應(yīng)用：WB、細胞**熒光、**組化、流式細胞術(shù)、ELISA、CHIP、IP和peptide array。
p90 RSK (phospho Thr573) Antibody
的詳細介紹
p90 RSK (phospho Thr573) AntibodyProduct Profile
|
Product Name
|
p90 RSK (phospho Thr573) Antibody
|
|
Antibody Type
|
Primary Antibodies
|
|
Product description
|
Serine/threonine-protein kinase that acts downstream of ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenic and stress-induced activation of the transcription factors CREB1, ETV1/ER81 and NR4A1/NUR77, regulates translation through RPS6 and EIF4B phosphorylation, and mediates cellular proliferation, survival, and differentiation by modulating mTOR signaling and repressing pro-apoptotic function of BAD and DAPK1. In fibroblast, is required for EGF-stimulated phosphorylation of CREB1, which results in the subsequent transcriptional activation of several immediate-early genes.1) Eiichi Takahashi, J. Biol. Chem., Jul 1999; 274: 20206.
More
|
|
Immunogen
|
p90 RSK (phospho Thr573) antibody was raised against a peptide sequence around phosphorylation site of threonine 573 (L-M-T (p)-P-C) derived from Human p90 RSK.
|
p90 RSK (phospho Thr573) AntibodyKey Feature
|
Clonality
|
Polyclonal
|
|
Isotype
|
IgG
|
|
Host Species
|
Rabbit
|
|
Tested Applications
|
IHCWB
|
|
|
Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100:
|
|
Species Reactivity
|
HumanMouseRat
|
|
Concentration
|
1mg/ml
|
|
Purification
|
Affinity purified
|
p90 RSK (phospho Thr573) AntibodyTarget Information
|
Gene Symbol
|
RPS6KA1
|
|
Alternative Names
|
KS6A1
p90RSK1
RSK1
RPS6KA1
More
|
|
Molecular Weight(MW)
|
95 kDa
|
|
Tissue Specificity
|
The antibody detects endogenous levels of P90RSK only when phosphorylated at threonine 573.
|
p90 RSK (phospho Thr573) AntibodyDatabase Links
|
Entrez Gene
|
6195
|
|
Protein Accession
|
NP_002944.2
|
p90 RSK (phospho Thr573) AntibodyApplication
-
Application
Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using p90 RSK (Phospho-Thr573) antibody (left) or the same antibody preincubated with blocking peptide (right).
-
Application
Western blot analysis of extracts from 293 cells treated with UV using p90 RSK (Phospho-Thr573) Antibody. The lane on the right is treated with the antigen-specific peptide.
|
Application Notes
|
Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100:
|
Additional Information
|
Form
|
Liquid
|
|
Storage Instructions
|
Store antibody at -20?C for up to one year.
|
|
Storage Buffer
|
Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
|
