FOS (phospho Thr232) Antibody
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產(chǎn)品名稱: FOS (phospho Thr232) Antibody
產(chǎn)品型號:
產(chǎn)品展商: immunoclone
產(chǎn)品文檔: 無相關(guān)文檔
簡單介紹
FOS (phospho Thr232) Antibody迅速增長的產(chǎn)品線包括一抗、二抗、**測定及細胞檢測試劑盒、蛋白/多肽、激動劑/拮抗劑/活化劑/抑制劑及裂解物等。FOS (phospho Thr232) Antibody嚴格的質(zhì)量控制和驗證實驗包括各種不同的應用：WB、細胞**熒光、**組化、流式細胞術(shù)、ELISA、CHIP、IP和peptide array。
FOS (phospho Thr232) Antibody
的詳細介紹
FOS (phospho Thr232) AntibodyProduct Profile
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Product Name
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FOS (phospho Thr232) Antibody
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Antibody Type
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Primary Antibodies
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Product description
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Nuclear phosphoprotein which forms a tight but non-covalently linked complex with the JUN/AP-1 transcription factor. In the heterodimer, FOS and JUN/AP-1 basic regions each seems to interact with symmetrical DNA half sites. On TGF-beta activation, forms a multimeric SMAD3/SMAD4/JUN/FOS complex at the AP1/SMAD-binding site to regulate TGF-beta-mediated signaling. Has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is thought to have an important role in signal transduction, cell proliferation and differentiation. In growing cells, activates phospholipid synthesis, possibly by activating CDS1 and PI4K2A. This activity requires Tyr-dephosphorylation and association with the endoplasmic reticulum.1) van Straaten F. Proc. Natl. Acad. Sci. U.S.A. 80:3183-3187(1983).
More
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Immunogen
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FOS (phospho Thr232) antibody was raised against a peptide sequence around phosphorylation site of threonine 232 (V-A-T (p)-P-E) derived from Human FOS .
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FOS (phospho Thr232) AntibodyKey Feature
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Clonality
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Polyclonal
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Isotype
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IgG
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Host Species
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Rabbit
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Tested Applications
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IHCWB
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Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100:
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Species Reactivity
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HumanMouse
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Concentration
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1mg/ml
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Purification
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Affinity purified
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FOS (phospho Thr232) AntibodyTarget Information
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Gene Symbol
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FOS
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Alternative Names
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FOS
G0S7
Cellular oncogene fos
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Molecular Weight(MW)
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48 kDa
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Tissue Specificity
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The antibody detects endogenous levels of FOS only when phosphorylated at threonine 232.
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FOS (phospho Thr232) AntibodyDatabase Links
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Entrez Gene
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2353
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Protein Accession
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NP_005243.1
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FOS (phospho Thr232) AntibodyApplication
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Application
Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using FOS (Phospho-Thr232) antibody (left) or the same antibody preincubated with blocking peptide (right).
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Application
Western blot analysis of extracts from COS7 cells (Lane 2), using FOS (Phospho-Thr232) Antibody. The lane on the left is treated with antigen-specific peptide.
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Application Notes
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Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100:
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Additional Information
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Form
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Liquid
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Storage Instructions
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Store antibody at -20?C for up to one year.
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Storage Buffer
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Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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