ABL1 / 2 (phospho Tyr393 / Tyr429) Antibody
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產(chǎn)品名稱: ABL1 / 2 (phospho Tyr393 / Tyr429) Antibody
產(chǎn)品型號:
產(chǎn)品展商: immunoclone
產(chǎn)品文檔: 無相關(guān)文檔
簡單介紹
ABL1 / 2 (phospho Tyr393 / Tyr429) Antibody迅速增長的產(chǎn)品線包括一抗、二抗、**測定及細(xì)胞檢測試劑盒、蛋白/多肽、激動劑/拮抗劑/活化劑/抑制劑及裂解物等。ABL1 / 2 (phospho Tyr393 / Tyr429) Antibody嚴(yán)格的質(zhì)量控制和驗(yàn)證實(shí)驗(yàn)包括各種不同的應(yīng)用：WB、細(xì)胞**熒光、**組化、流式細(xì)胞術(shù)、ELISA、CHIP、IP和peptide array。
ABL1 / 2 (phospho Tyr393 / Tyr429) Antibody
的詳細(xì)介紹
ABL1 / 2 (phospho Tyr393 / Tyr429) AntibodyProduct Profile
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Product Name
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ABL1 / 2 (phospho Tyr393 / Tyr429) Antibody
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Antibody Type
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Primary Antibodies
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Product description
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Regulates cytoskeleton remodeling during cell differentiation, cell division and cell adhesion. Localizes to dynamic actin structures, and phosphorylates CRK and CRKL, DOK1, and other proteins controlling cytoskeleton dynamics. Regulates DNA repair potentially by activating the proapoptotic pathway when the DNA damage is too severe to be repaired. Phosphorylates PSMA7 that leads to an inhibition of proteasomal activity and cell cycle transition blocks.1) Wang, J. Y. et al. (2000) Oncogene 19, 5643-5650. Danial, N. N. et al. (2000) Oncogene 19, 2523-2531. Brasher, B. B. et al. (2000) J. Biol. Chem. 275, 35631-35637. Pluk, H. et al. (2002) Cell 108, 247-259.
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Immunogen
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ABL1/2 (phospho-Tyr393/429) antibody was raised against a peptide sequence around phosphorylation site of tyrosine 393/429 (D-T-Y (p) -T-A) derived from Human ABL1/2.
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ABL1 / 2 (phospho Tyr393 / Tyr429) AntibodyKey Feature
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Clonality
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Polyclonal
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Host Species
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Rabbit
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Tested Applications
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IFIHCWB
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Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100, Immunofluorescence: 1:100~1:200:
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Species Reactivity
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HumanMouse
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Concentration
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1mg/ml
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Purification
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Affinity purified
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ABL1 / 2 (phospho Tyr393 / Tyr429) AntibodyTarget Information
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Gene Symbol
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ABL1 ABL2
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Alternative Names
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ABL
JTK7
p150
c-ABL
v-abl
c-ABL1
bcr/abl
BHLHE39
Abelson murine leukemia viral oncogene homolog 1
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Molecular Weight(MW)
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210 kDa
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Tissue Specificity
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This antibody detects endogenous level of ABL1/2 only when phosphorylated at tyrosine393/429.
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ABL1 / 2 (phospho Tyr393 / Tyr429) AntibodyDatabase Links
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Entrez Gene
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25 / 27
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Protein Accession
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NP_005148.2 / NP_001129472.1
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ABL1 / 2 (phospho Tyr393 / Tyr429) AntibodyApplication
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Application
Western blot analysis of lysed extracts from HL60 cells using ABL1/2 (phospho-Tyr393/429).
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Application
Top Image: Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using ABL1/2 (Phospho-Tyr393/429). Bottom Image: Immunofluorescence staining of methanol-fixed HeLa cells using ABL1/2 (phospho-Tyr393/429).
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Application Notes
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Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100, Immunofluorescence: 1:100~1:200:
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Additional Information
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Form
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Liquid
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Storage Instructions
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Store antibody at -20?C for up to one year.
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Storage Buffer
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Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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