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產(chǎn)品名稱: NMDA NR1 Antibody
產(chǎn)品型號:
產(chǎn)品展商: immunoclone
產(chǎn)品文檔: 無相關(guān)文檔
簡單介紹
NMDA NR1 Antibody迅速增長的產(chǎn)品線包括一抗、二抗、**測定及細(xì)胞檢測試劑盒、蛋白/多肽、激動劑/拮抗劑/活化劑/抑制劑及裂解物等。NMDA NR1 Antibody嚴(yán)格的質(zhì)量控制和驗證實驗包括各種不同的應(yīng)用：WB、細(xì)胞**熒光、**組化、流式細(xì)胞術(shù)、ELISA、CHIP、IP和peptide array。
NMDA NR1 Antibody
的詳細(xì)介紹
NMDA NR1 AntibodyProduct Profile
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Product Name
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NMDA NR1 Antibody
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Antibody Type
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Primary Antibodies
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Product description
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The ion channels activated by glutamate are typically divided into two classes. Those that are sensitive to N-methyl-D-aspartate (NMDA) are designated NMDA receptors (NMDAR). The NMDAR plays an essential role in memory, neuronal development and it has also been implicated in several disorders of the central nervous system including Alzheimer’s disease, epilepsy and ischemic neuronal cell death. Increased membrane surface expression of the NR1 subunit of the receptor has been associated with synaptic plasticity. There are a number of different splice variants of the NR1. Differential splicing of three exons in the NR1 subunit generates up to eight NR1 splice variants and 7 of these have been identified in cDNA libraries. These exons encode a 21 amino acid N-terminal domain (N1) and adjacent sequences in the C-terminus (C1 and C2). Splicing out the C2 cassette eliminates the first stop codon and produces a new reading frame that generates a new sequence of 22 amino acids (C2'). Considerable attention has been focused on the distribution and expression of these splice variants that may affect the functional properties and regulation of the NMDAR.1) Grosshans, D.R., Clayton, D.A., Coultrap, S.J., and Browning, M.D., "LTP leads to rapid surface expression on NMDA not AMPA receptors in ***** rat CA1," Nature Neurosci., 5 (2002) 27 - 33.
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Immunogen
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NMDA NR1, Splice Variant C2’ polyclonal antibody was raised against a peptide containing the C2’ insert.
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NMDA NR1 AntibodyKey Feature
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Clonality
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Polyclonal
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Host Species
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Rabbit
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Tested Applications
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IHCWB
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NMDA NR1, Splice Variant C2' antibody allows for strong and specific immunolabeling of the NR1 subunit containing the C2’ splice variant insert. Rabbit anti-NMDA NR1, Splice Variant C2’ does not recognize NR1 subunits that do not contain the C2’ insert. Applications include Dot Blots (DB), Immunohistochemistry (IHC) and Western Blots (WB). Rabbit anti-NMDA NR1, Splice Variant C2 recognizes NR1 in rat and mouse brain. When internally tested under ideal conditions the working dilutions were 1:1000 for IHC, DB and WB.:
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Species Reactivity
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Rat
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Concentration
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1mg/ml
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Purification
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Affinity purified
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NMDA NR1 AntibodyTarget Information
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Gene Symbol
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Grin1
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Alternative Names
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NR1
GluN1
NMDAR1
Nmdar1
N-methyl-D-aspartate receptor subunit NR1
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Molecular Weight(MW)
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120
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NMDA NR1 AntibodyDatabase Links
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Entrez Gene
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24408
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Protein Accession
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P35439
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NMDA NR1 AntibodyApplication
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Application
NMDA NR1, Splice Variant C2' Antibody
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Application Notes
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NMDA NR1, Splice Variant C2' antibody allows for strong and specific immunolabeling of the NR1 subunit containing the C2’ splice variant insert. Rabbit anti-NMDA NR1, Splice Variant C2’ does not recognize NR1 subunits that do not contain the C2’ insert. Applications include Dot Blots (DB), Immunohistochemistry (IHC) and Western Blots (WB). Rabbit anti-NMDA NR1, Splice Variant C2 recognizes NR1 in rat and mouse brain. When internally tested under ideal conditions the working dilutions were 1:1000 for IHC, DB and WB.:
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Additional Information
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Form
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Liquid
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Storage Instructions
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NMDA NR1, Splice Variant C2' antibody can be stored at -20?C. After reconstitution in 50 μl PBS, the antibody should be aliquot and stored at -20?C and is stable at -20?C for at least 1 year. Ambient shipment is suitable for both international and domestic.
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Storage Buffer
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phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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