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產(chǎn)品名稱: Mouse Irf3 Antibody
產(chǎn)品型號(hào):
產(chǎn)品展商: immunoclone
產(chǎn)品文檔: 無相關(guān)文檔
簡(jiǎn)單介紹
Mouse Irf3 Antibody迅速增長(zhǎng)的產(chǎn)品線包括一抗、二抗、**測(cè)定及細(xì)胞檢測(cè)試劑盒、蛋白/多肽、激動(dòng)劑/拮抗劑/活化劑/抑制劑及裂解物等。Mouse Irf3 Antibody嚴(yán)格的質(zhì)量控制和驗(yàn)證實(shí)驗(yàn)包括各種不同的應(yīng)用：WB、細(xì)胞**熒光、**組化、流式細(xì)胞術(shù)、ELISA、CHIP、IP和peptide array。
Mouse Irf3 Antibody
的詳細(xì)介紹
Mouse Irf3 AntibodyProduct Profile
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Product Name
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Mouse Irf3 Antibody
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Antibody Type
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Primary Antibodies
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Product description
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Mediates interferon-stimulated response element (ISRE) promoter activation. Functions as a molecular switch for antiviral activity. DsRNA generated during the course of an viral infection leads to IRF3 phosphorylation on the C-terminal serine/threonine cluster. This induces a conformational change, leading to its dimerization, nuclear localization and association with CREB binding protein (CREBBP) to form dsRNA-activated factor 1 (DRAF1), a complex which activates the transcription of genes under the control of ISRE. The complex binds to the IE and PRDIII regions on the IFN-alpha and IFN-beta promoters respectively. IRF-3 does not have any transcription activation domains (By similarity).1) Marichal, T., et al. J. Allergy Clin. Immunol. 126(4):836-844(2010)
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Immunogen
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This Mouse Irf3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 46-72 amino acids from the N-terminal region of mouse Irf3.
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Mouse Irf3 AntibodyKey Feature
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Clonality
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Polyclonal
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Isotype
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Ig
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Host Species
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Rabbit
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Tested Applications
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WB
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For WB starting dilution is: 1:1000:
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Species Reactivity
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Mouse
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Concentration
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1mg/ml
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Purification
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Affinity purified
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Mouse Irf3 AntibodyTarget Information
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Gene Symbol
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Irf3
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Alternative Names
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Interferon regulatory factor 3
IRF-3
Irf3
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Molecular Weight(MW)
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47 kDa
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Sequence Similarities
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Predicted species reactivity based on immunogen sequence: Bovine
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Mouse Irf3 AntibodyDatabase Links
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Entrez Gene
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54131
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Protein Accession
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P70671
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Mouse Irf3 AntibodyApplication
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Application
Western blot analysis in mouse liver tissue lysates (35ug/lane).
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Application Notes
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For WB starting dilution is: 1:1000:
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Mouse Irf3 AntibodyMouse Irf3 AntibodyAdditional Information
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Form
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Liquid
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Storage Instructions
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Store at 4?C for three months and -20?C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
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Storage Buffer
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Supplied in PBS with 0.09% (W/V) sodium azide.
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