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產(chǎn)品資料

Connexin Antibody

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產(chǎn)品名稱: Connexin Antibody
產(chǎn)品型號:
產(chǎn)品展商: immunoclone
產(chǎn)品文檔: 無相關(guān)文檔

簡單介紹

Connexin Antibody迅速增長的產(chǎn)品線包括一抗、二抗、**測定及細胞檢測試劑盒、蛋白/多肽、激動劑/拮抗劑/活化劑/抑制劑及裂解物等。Connexin Antibody嚴格的質(zhì)量控制和驗證實驗包括各種不同的應(yīng)用：WB、細胞**熒光、**組化、流式細胞術(shù)、ELISA、CHIP、IP和peptide array。


Connexin Antibody  的詳細介紹

Connexin AntibodyProduct Profile

Product Name Connexin Antibody
Antibody Type Primary Antibodies
Product description 
					

						Gap junctional intercellular communication is thought to play a key role in development and may also be involved in epilepsy (Aronica et al., 2001). Connexin43 forms gap-junctional channels and regulates the permeability of these gap junctions to small organic molecules. Permeability of connexin43 is known to be regulated by phosphorylation at er368 by protein kinase C (Yogo et al., 2002; Bao et al., 2004a). Phosphorylation of Ser368 by PKC induces a conformational change of connexin43 that results in a decrease in gap junction permeability (Bao et al., 2004b).1) Aronica E, Gorter JA, Jansen GH, Leenstra S, Yankaya B, Troost D (2001) Expression of connexin 43 and connexin 32 gap-junction proteins in epilepsy-associated brain tumors and in the perilesional epileptic cortex. Acta Neuropathol (Berl) 101:449-459.
					

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Immunogen 
Peptide corresponding to amino acid residues from the C-terminal region of rat connexin43.

Connexin AntibodyKey Feature

Clonality Polyclonal
Host Species Rabbit
Tested Applications

WB

The antibody has been directly tested for reactivity in Western blots in rat tissues. It is anticipated that the antibody will also work with chicken, dog, finch, human, mouse, non-human primate, sheep, Xenopus and zebra fish tissues based on the fact that these species have 100% homology with the amino acid sequence used as antigen.:
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Species Reactivity

ChickenDogHumanMouseRatSheepXenopusZebra Fish

Concentration 1mg/ml
Purification Affinity purified

Connexin AntibodyTarget Information

Gene Symbol Gja1
Alternative Names
Cx43
Cxn-43
Connexin-43
Cx43
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Molecular Weight(MW) 43

Connexin AntibodyDatabase Links

Entrez Gene 24392
Protein Accession P08050

Connexin AntibodyApplication

  • Application

    Western blot of rat cerebellar lysate showing specific immunolabeling of the ~43k connexin43 protein.

Application Notes
The antibody has been directly tested for reactivity in Western blots in rat tissues. It is anticipated that the antibody will also work with chicken, dog, finch, human, mouse, non-human primate, sheep, Xenopus and zebra fish tissues based on the fact that these species have 100% homology with the amino acid sequence used as antigen.:
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Additional Information

Form Liquid
Storage Instructions Connexin antibody can be stored at -20?C and is stable at -20?C for at least 1 year.
Storage Buffer 100 uL in 10 mM HEPES (pH 7.5), 150 mM NaCl, 100 ug per mL BSA and 50% glycerol.

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